The field of Neuroscience has a history of informing many other disciplines such as medicine, communication, political science, business, and now education. CRADLE approaches the study of learning and thinking through educational neuroscience by employing neuropsychological principles coupled with advanced neuroimaging and behavioural methodologies. In the near term, we seek to uncover the behavioural and neurophysiological substrates of learning and emotion, and their interactions, to inform motivation-based learning. This understanding supports the development of e-Learning platforms. These platforms can then be tested within Singapore’s cosmopolitan setting to study cross-cultural thinking patterns. Educational neuroscience is also important to life-long learning with respect to neuroplasticity of brain development and the brain's response to cognitive interventions.